2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-136596
    Apalutamide-COOH
    		99.76%
    Apalutamide-COOH is a metabolite of Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM.
    Apalutamide-COOH
  • HY-103005
    Ramelteon metabolite M-II
    		98.24%
    Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist.
    Ramelteon metabolite M-II
  • HY-W009934
    2-Phenyl-2-(2-pyridyl)acetonitrile
    		99.97%
    2-Phenyl-2-(2-pyridyl)acetonitrile is the major metabolite of SC 15396 metabolized by the supernatant fraction of rat liver homogenate. SC 15396 is an antigastrin that inhibits gastric secretion.
    2-Phenyl-2-(2-pyridyl)acetonitrile
  • HY-125947
    4-Epioxytetracycline
    		99.16%
    4-Epioxytetracycline, the degradation product of Oxytetracycline (OTC), can be found in swine manure compost and wastewater.
    4-Epioxytetracycline
  • HY-400648
    Folic acid methyl ester
    		99.12%
    Folic acid methyl ester is a methyl ester metabolite of folic acid that can be used in the study of neuropsychiatric conditions, such as depression[1].
    Folic acid methyl ester
  • HY-153695
    TXA707
    TXA707, the active metabolite of TXA-709, is an FtsZ inhibitor with antibacterial activity. TXA707 is promising for research of S. aureus infections.
    TXA707
  • HY-12388AS
    N-Desmethyl clomipramine-d3 hydrochloride
    		99.81%
    N-Desmethyl Clomipramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine
    N-Desmethyl clomipramine-d<sub>3</sub> hydrochloride
  • HY-128379
    Labetalone hydrochloride
    		99.27%
    Labetalone hydrochloride is an impurity of Labetalol. Labetalol is an orally active adrenoceptor blocking agent which is a competitive antagonist at both alpha- and beta-adrenoceptor sites.
    Labetalone hydrochloride
  • HY-W042214
    Ritalinic acid
    		99.81%
    Ritalinic acid (Ritalinate) is the main inactive urinary metabolite of Methylphenidate. Methylphenidate has the potential for attention-deficit hyperactivity disorder and narcolepsy research.
    Ritalinic acid
  • HY-B1259
    6-Acetamidohexanoic acid
    		≥98.0%
    6-Acetamidohexanoic acid is a metabolite of hexamethylene bisacetamide (HY-124284). 6-Acetamidohexanoic acid is less active than the parent compound HMBA and cannot induce cell differentiation.
    6-Acetamidohexanoic acid
  • HY-138253S
    2′,2′-Difluorodeoxyuridine-13C,15N2
    		99.50%
    2′,2′-Difluorodeoxyuridine-13C,15N2 (dFdU-13C,15N2) is a 13C- and 15N-labeled compound. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells.
    2′,2′-Difluorodeoxyuridine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-131492
    Δ4-Dafachronic acid
    Δ4-Dafachronic acid is an agonist of DAF-12 and a metabolite of cholesterol.
    Δ4-Dafachronic acid
  • HY-129697
    3-Hydroxy Medetomidine
    		≥98.0%
    3-Hydroxy Medetomidine (3-OH Medetomidine; Medetomidine metabolite MIII) is a metabolite of the α2-adrenergic receptor agonist medetomidine.
    3-Hydroxy Medetomidine
  • HY-136498A
    T-705RMP ammonium
    T-705RMP (ammonium) is the ammonium form of T-705RMP. T-705RMP (ammonium)’s the inhibition of IMP dehydrogenase (IMPDH) activity is weak .
    T-705RMP ammonium
  • HY-B1103
    Hydroxyhexamide
    		99.60%
    Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.
    Hydroxyhexamide
  • HY-116909
    O-Methylsterigmatocystin
    		99.3%
    O-Methylsterigmatocystin is a metabolite in Aspergillus flavus and Aspergillus parasiticus.
    O-Methylsterigmatocystin
  • HY-N11678
    Deoxynivalenol-3-β-D-glucoside
    		98.69%
    Deoxynivalenol-3-β-D-glucoside (DON-3-β-D-glucoside) is a plant metabolite of the Fusarium mycotoxin Deoxynivalenol (HY-N6684). Deoxynivalenol-3-β-D-glucoside exhibits lower toxicity than Deoxynivalenol in vitro and in vivo.
    Deoxynivalenol-3-β-D-glucoside
  • HY-10002R
    Calcitriol (Standard)
    Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
    Calcitriol (Standard)
  • HY-126857S
    5-Hydroxy Omeprazole-d3
    		98.27%
    5-Hydroxy Omeprazole-d3 is deuterium labeled 5-Hydroxyomeprazole.
    5-Hydroxy Omeprazole-d<sub>3</sub>
  • HY-N10889
    Sominone
    Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease.
    Sominone
Cat. No. Product Name / Synonyms Application Reactivity