2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-138166
    Rosuvastatin lactone
    		98.56%
    Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A) (HMG-CoA inhibitor).
    Rosuvastatin lactone
  • HY-133675
    Mono(5-carboxy-2-ethylpentyl) phthalate
    Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking.
    Mono(5-carboxy-2-ethylpentyl) phthalate
  • HY-123349
    5α-Hydroxy-6-keto cholesterol
    		≥99.0%
    5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM.
    5α-Hydroxy-6-keto cholesterol
  • HY-103005
    Ramelteon metabolite M-II
    		98.24%
    Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist.
    Ramelteon metabolite M-II
  • HY-N7686
    Paeoniflorgenin
    Paeoniflorgenin is a deglucosylated metabolite of Paeoniflorin.
    Paeoniflorgenin
  • HY-136336
    Tofacitinib metabolite-1
    		99.59%
    Tofacitinib metabolite-1 is a metabolite of Tofacitinib, a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib.
    Tofacitinib metabolite-1
  • HY-148053
    Rezivertinib analogue 1
    		99.00%
    Rezivertinib analogue 1 is a process impurity of osimertinib mesylate. Rezivertinib analogue 1 can be used in the study of non-small cell lung cancer.
    Rezivertinib analogue 1
  • HY-W042214
    Ritalinic acid
    		99.81%
    Ritalinic acid (Ritalinate) is the main inactive urinary metabolite of Methylphenidate. Methylphenidate has the potential for attention-deficit hyperactivity disorder and narcolepsy research.
    Ritalinic acid
  • HY-B2121
    6-Methoxy-2-naphthoic acid
    		99.73%
    6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone (HY-B0559). 6-Methoxy-2-naphthoic acid is also an inhibitor of COX-1 and COX-2. 6-Methoxy-2-naphthoic acid can inhibit the synthesis of gastric mucosal prostaglandin E2. 6-Methoxy-2-naphthoic acid can be used in the research of inflammation and pain-related diseases. In addition, 6-Methoxy-2-naphthoic acid is an impurity in Naproxen (HY-15030) and can also be used in the synthesis of other active compounds.
    6-Methoxy-2-naphthoic acid
  • HY-W013186
    Lansoprazole sulfide
    		99.91%
    Lansoprazole sulfide is an active metabolite of Lansoprazole by cytochrome P450, possesses anti-cancer activity. Lansoprazole sulfide is an anti-tuberculous agent, with an IC50 of 0.59 µM for M. tb.
    Lansoprazole sulfide
  • HY-113483
    20-Carboxy-Leukotriene B4
    		98.0%
    20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608). 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis).
    20-Carboxy-Leukotriene B4
  • HY-118025
    (±)-2-Oxo clopidogrel
    		99.67%
    (±)-2-Oxo clopidogrel is a metabolite of the antiplatelet agent Clopidogrel (HY-15283).
    (±)-2-Oxo clopidogrel
  • HY-B1259
    6-Acetamidohexanoic acid
    		≥98.0%
    6-Acetamidohexanoic acid is a metabolite of hexamethylene bisacetamide (HY-124284). 6-Acetamidohexanoic acid is less active than the parent compound HMBA and cannot induce cell differentiation.
    6-Acetamidohexanoic acid
  • HY-133010
    Tamoxifen N-oxide
    Tamoxifen N-oxide is a Tamoxifen (HY-13757A) metabolite.
    Tamoxifen N-oxide
  • HY-131492
    Δ4-Dafachronic acid
    Δ4-Dafachronic acid is an agonist of DAF-12 and a metabolite of cholesterol.
    Δ4-Dafachronic acid
  • HY-136498A
    T-705RMP ammonium
    T-705RMP (ammonium) is the ammonium form of T-705RMP. T-705RMP (ammonium)’s the inhibition of IMP dehydrogenase (IMPDH) activity is weak .
    T-705RMP ammonium
  • HY-W016034
    Acetaminophen glucuronide sodium salt
    		≥99.0%
    Acetaminophen glucuronide is a safe and effective antipyretic analgesic. Acetaminophen glucuronide is potentially toxic to liver and kidney .
    Acetaminophen glucuronide sodium salt
  • HY-129072
    Isocyclosporin A
    		98.5%
    Isocyclosporin A is a degradation product of the immunosuppressant Cyclosporin A.
    Isocyclosporin A
  • HY-W747072
    3-Sulfo-taurocholic Acid Disodium Salt
    		99.0%
    3-Sulfo-taurocholic Acid Disodium Salt (3-Sulfocholyl Taurine; TCA3S) is a metabolite of the conjugated bile acid taurocholic acid. Plasma levels of 3-Sulfo-taurocholic Acid Disodium Salt are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated in Sort1 knockout mice at 24 hours post-BDL.
    3-Sulfo-taurocholic Acid Disodium Salt
  • HY-101671
    S-methyl-KE-298
    		≥98.0%
    S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
    S-methyl-KE-298
Cat. No. Product Name / Synonyms Application Reactivity